Results 121 to 130 of about 3,096,902 (313)

The VA Rural Interprofessional Faculty Development Initiative: a qualitative evaluation guided by the RE-AIM framework

BMC Medical Education
Background The Department of Veterans Affairs (VA) Rural Interprofessional Faculty Development Initiative (RIFDI) is a longitudinal, multimodal training program designed to improve the quality of and capacity for health professions education in rural ...
Sarah Keithly, Paige Perry, Erica J. Ho, Ryan A. Sterling, Soumya Subramaniam, Shaina Coogan, Sarah E. Shirley, George Sayre, Christian Helfrich, Charles Maynard, Catherine P. Kaminetzky, Erin L. Patel, Joseph Chiovaro, Joel Schmidt, Rebecca Stout, Amber Fisher, Edwin S. Wong, Megan Moldestad   +17 more
doaj   +1 more source

The Regional Impact of Health Care Expenditure: the Case of Italy [PDF]

Decentralisation invests the sub-central authorities of a country with autonomy in political and economic power the exercise of which may widen interregional divergence and inequality.
Margherita Giannoni, Theodore Hitiris
core  

Design of a wireless patient diagnosis system [PDF]

, 2012
Medical administrative and diagnosis procedures require the retrieval of patient diagnosis history before treatments and drug administration. This involves careful checking of the patient past record which might be stored electronically or in paper ...
Holmes, Violeta, Jimoh, F.
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reflexões sobre o papel das unidades de economia da saúde no âmbito de sistemas nacionais de saúde

Saúde e Sociedade
Resumo O objetivo deste texto é apresentar algumas reflexões sobre o papel e a relevância das unidades de economia da saúde (UES) no âmbito de sistemas nacionais de saúde.
Fabiola Sulpino Vieira
doaj   +1 more source

The Price of Jails: Measuring the Taxpayer Cost of Local Incarceration [PDF]

, 2015
Jails are far more expensive than previously understood, as significant jail expenditures -- such as employee salaries and benefits, health care and education programs for incarcerated people, and general administration -- are paid for by county or ...
Christian Henrichson, Joshua Rinaldi, Ruth Delaney   +2 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source