Results 51 to 60 of about 837,452 (256)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Effects of a post-acute care management program on subsequent acute care utilization for hospitalized patients discharged to skilled nursing facilities

BMC Health Services Research
Background Post-acute care management programs are designed to optimize transitions from hospitals to skilled nursing facilities (SNFs) and reduce acute care utilization but largely focus on Medicare beneficiaries. Little is known about the effectiveness
Devon Armstrong, Afiba M.-A. Agovi, Aaron W. Gehr, Matthew Cvitanovich, Elyse McNamara-Pittler, Nydia Goodier, Kendra Hasty, Amy Govea, Maria Woods, Rohit P. Ojha   +9 more
doaj   +1 more source

Attitudes and Behavior of Health Care Workers Before, During, and After Implementation of Real-Time Location System Technology

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Objective: To assess how staff attitudes before, during, and after implementation of a real-time location system (RTLS) that uses radio-frequency identification tags on staff and patient identification badges and on equipment affected staff’s intention ...
Joan M. Griffin, PhD, Thomas R. Hellmich, MD, Kalyan Sunder Pasupathy, PhD, Shealeigh A. Funni, BS, Skylar M. Pagel, BS, Sankara Subramanian Srinivasan, PhD, Heather A. Heaton, MD, MAS, Mustafa Y. Sir, PhD, David M. Nestler, MD, MS, Renaldo C. Blocker, PhD, Hunter J. Hawthorne, BS, Kyle R. Koenig, PMP, Kelly M. Herbst, BEd, M. Susan Hallbeck, PhD   +13 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Experiences and lessons learned from a patient‐engagement service established by a national research consortium in the U.S. Veterans Health Administration

Learning Health Systems
Introduction Meaningful engagement of patients in the research process has increased over the past 20 years. Few accounts are available of engagement infrastructure and processes used by large research organizations.
Tracy L. Sides, Agnes C. Jensen, Malloree M. Argust, Erin C. Amundson, Gay R. Thomas, Rebecca Keller, Mallory Mahaffey, Erin E. Krebs   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Maternal decision‐making for patients offered prenatal myelomeningocele repair

Pregnancy
Introduction To explore the decision‐making process for patients offered prenatal myelomeningocele repair. Methods This single‐center prospective cohort study enrolled women who were candidates for prenatal myelomeningocele repair. Participants completed
Laura C. Colicchia, Saul Snowise, Whitney Wunderlich, Jessica Taghon, Anna K. Schulte, Ian Wolfe, Abbey C. Sidebottom   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source