Results 61 to 70 of about 15,670,415 (297)

Evaluating adoption and reach in a pragmatic randomized trial of community paramedicine for intermediate acuity patient care

Journal of Clinical and Translational Science
Introduction: Pragmatic trials aim to speed translation to practice by integrating study procedures in routine care settings. This study evaluated implementation outcomes related to clinician and patient recruitment and participation in a trial of ...
Jennifer L. Ridgeway, Wendy J. S. Sundt, Tami S. Krpata, Amy Glasgow, Olivia A. Smith, Michelle A. Lampman, Jamie L. Smith-Stellflug, Terri L. Menser, Michael B. Juntunen, Chad P. Liedl, Joseph G. Hentz, Jessica J. McCoy, Rozalina G. McCoy   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Controlled Substance Agreements for Opioids in a Primary Care Practice

Journal of Pharmaceutical Policy and Practice, 2017
Background Opioids are widely prescribed for chronic non cancer pain (CNCP). Controlled substance agreements (CSAs) are intended to increase adherence and mitigate risk with opioid prescribing.
Lindsey M. Philpot, Priya Ramar, Muhamad Y. Elrashidi, Raphael Mwangi, Frederick North, Jon O. Ebbert   +5 more
doaj   +1 more source

Abstracts From the 2025 Health Care Systems Research Network (HCSRN) Annual Conference, St. Louis, Missouri

The Health Care Systems Research Network (HCSRN) comprises 19 learning health systems with integrated care delivery and embedded research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate ...
Research Network, Health Care Systems
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effects of a post-acute care management program on subsequent acute care utilization for hospitalized patients discharged to skilled nursing facilities

BMC Health Services Research
Background Post-acute care management programs are designed to optimize transitions from hospitals to skilled nursing facilities (SNFs) and reduce acute care utilization but largely focus on Medicare beneficiaries. Little is known about the effectiveness
Devon Armstrong, Afiba M.-A. Agovi, Aaron W. Gehr, Matthew Cvitanovich, Elyse McNamara-Pittler, Nydia Goodier, Kendra Hasty, Amy Govea, Maria Woods, Rohit P. Ojha   +9 more
doaj   +1 more source

Attitudes and Behavior of Health Care Workers Before, During, and After Implementation of Real-Time Location System Technology

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Objective: To assess how staff attitudes before, during, and after implementation of a real-time location system (RTLS) that uses radio-frequency identification tags on staff and patient identification badges and on equipment affected staff’s intention ...
Joan M. Griffin, PhD, Thomas R. Hellmich, MD, Kalyan Sunder Pasupathy, PhD, Shealeigh A. Funni, BS, Skylar M. Pagel, BS, Sankara Subramanian Srinivasan, PhD, Heather A. Heaton, MD, MAS, Mustafa Y. Sir, PhD, David M. Nestler, MD, MS, Renaldo C. Blocker, PhD, Hunter J. Hawthorne, BS, Kyle R. Koenig, PMP, Kelly M. Herbst, BEd, M. Susan Hallbeck, PhD   +13 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Experiences and lessons learned from a patient‐engagement service established by a national research consortium in the U.S. Veterans Health Administration

Learning Health Systems
Introduction Meaningful engagement of patients in the research process has increased over the past 20 years. Few accounts are available of engagement infrastructure and processes used by large research organizations.
Tracy L. Sides, Agnes C. Jensen, Malloree M. Argust, Erin C. Amundson, Gay R. Thomas, Rebecca Keller, Mallory Mahaffey, Erin E. Krebs   +7 more
doaj   +1 more source