Results 121 to 130 of about 4,397,138 (309)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Health Care Waste Management: Are we Serious ?

Journal of Clinical and Biomedical Sciences, 2015
Dr. S . Pruthvish
doaj   +1 more source

Patient Experience and Satisfaction with an e-Health Care Management Application for Inflammatory Bowel Diseases. [PDF]

Int J Environ Res Public Health, 2021
Zand A, Nguyen A, Reynolds C, Khandadash A, Esrailian E, Hommes D.   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Waste Management in Selected Hospitals of Teheran University of Medical Sciences: Staff Awareness and Hospital Performance -2012

بیمارستان, 2014
Background: Hospital waste is one of the environmental problems .Ignoring the proper management of these wastes can lead to outbreak of diseases and epidemics which threat the public health and rise high costs as a result.
E Zeraatkar, H Rahmani, M Ghazi Asgar, J Saeid Pour, S Azami, A Aryankhesal, M pakdaman   +6 more
doaj  

Development and Psychometric Validation of the Hospital Medication System Safety Assessment Questionnaire

Nursing Reports
Background/Objectives: Medication incidents remain a significant concern in hospital settings. Integrated medication systems, regarding organized processes, policies, technologies and professional practices are designed to enhance patient safety; however,
Leila Sales, Ana Filipa Cardoso, Beatriz Araújo, Élvio Jesus   +3 more
doaj   +1 more source

Moving Care to the Community: An International Perspective [PDF]

, 2013
Medical treatments that were once provided in hospital are being increasingly administered in the community. Within health systems, there is a renewed focus on delivering general health care in the community, freeing hospitals to provide more complex ...

core  

Digital Orthopaedics: A Glimpse Into the Future in the Midst of a Pandemic. [PDF]

, 2020
BackgroundThe response to COVID-19 catalyzed the adoption and integration of digital health tools into the health care delivery model for musculoskeletal patients. The change, suspension, or relaxation of Medicare and federal guidelines enabled the rapid
Ast, Michael P, Bini, Stefano A, Chung, Christopher C, Kalore, Niraj V, Lawrie, Charles M, Maratt, Joseph D, Patel, Shaun P, Schilling, Peter L, Schuett, Dustin J, Steele, G Daxton   +9 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluation of Three Blended Learning Courses to Strengthen Health Professionals' Capacity in Primary Health Care, Management of Sexual and Reproductive Health Services and Research Methods in Guinea. [PDF]

Front Digit Health, 2022
Millimouno TM, Delvaux T, Kolié JM, Kourouma K, Van Bastelaere S, Tsunami CK, Béavogui AH, Garcia M, Van Damme W, Delamou A.   +9 more
europepmc   +1 more source