Results 31 to 40 of about 1,684,097 (218)

Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a cross-sectional study

BMC Geriatrics, 2022
Background The objective was to describe the prevalence and intensity of neuropsychiatric symptoms (NPSs) isolated and grouped into subsyndromes in patients with dementia in primary care (PC) to analyse their distribution based on stages of dementia and ...
Victoria García-Martín, M. Canto de Hoyos-Alonso, Gloria Ariza-Cardiel, Rosalía Delgado-Puebla, Paula García-Domingo, Erika Hernández-Melo, Javier López de Haro-de Torres, Isabel del Cura-González   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The concept of economic security of the hospital: a new look at the levers of control

Forum Scientiae Oeconomia, 2014
Despite a significant progress achieved in the healthcare sector during last decades, we need to admit the fact that many urgent problems remain unsolved even in well developed countries. Along with other major factors, economic causes of these problems
Yuliya Shutyak, Didier Van Caillie
doaj  

Perspectives of old-age and dementia researchers on communication with policymakers and public research funding decision-makers: an international cross-sectional survey

Frontiers in Medicine
IntroductionSociety commonly believes that research knowledge is complementary to public decision-making. This study aimed to understand the perspectives and implications of dementia researchers communicating with policymakers and public research ...
Peter Fusdahl, Peter Fusdahl, Miguel Germán Borda, Miguel Germán Borda, Miguel Germán Borda, Jonathan Patricio Baldera, Dag Aarsland, Dag Aarsland, Ara Khachaturian, Ara Khachaturian, Ara Khachaturian, Ara Khachaturian, Geir Sverre Braut, Geir Sverre Braut   +13 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An evolved perspective on critical thinking in health care managers: A concept analysis

Chronic Diseases Journal
Background: Leaders are tasked with making decisions that have substantial impact on an organization's well-being. Decision making requires critical thinking. Clinical environments are becoming more complex and demanding nowadays. Acquisition of critical
Hussein Saber Hussein, Kaveh Bahmanpour, Mohammad Fathi, Adel Fatemi   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

System‐failing creativity in health care

Learning Health Systems
Introduction Health care professionals often generate novel solutions to solve problems during day‐to‐day patient care. However, less is known about generating novel and useful (i.e., creative) ideas in the face of health care system failure.
Stijn Horck, Rachel E. Gifford, Bram P. I. Fleuren, Cheryl Rathert, Tracy H. Porter, Afshan Rauf, Yuna S. H. Lee   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source