Results 81 to 90 of about 918,627 (316)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease : 5-year follow-up of multicentre randomised trial (the REFLUX trial) [PDF]

, 2013
Peer ...
C Boachie, R Faria, M Sculpher, Faria, R, Ramsay, C R, Sculpher, M, RC Heading, L Bojke, Campbell, M K, AM Grant, Krukowski, Z H, ZH Krukowski, Corbacho, B, DM Epstein, Bojke, L, Cotton, S C, SC Cotton, CR Ramsay, Heading, R C, B Corbacho, MK Campbell, Grant, A M, Epstein, D M, Boachie, C   +23 more
core   +1 more source

Assessment of mental and physical health outcomes over time in an integrated care setting

BMC Primary Care
Integrated care addresses the fragmentation of patient health services and potentially improves the experience of care, reduces healthcare costs, and improves health outcomes. This study assessed the improvements in mental health and physical health outcomes among patients living with mental health challenges and treated in an integrated care setting ...
Dependra Bhatta, Monteic A. Sizer, Binod Acharya, Dipendra Banjara   +3 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Investigating Patient Outcome Measures in Mental Health [PDF]

This report examines the feasibility of incorporating patient outcomes in mental health into a productivity measure. It examines which outcome measures are most commonly used in mental health, the practical issues about collecting these outcome measures,
Rowena Jacobs
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A qualitative process evaluation of electronic session-by-session outcome measurement in child and adolescent mental health services [PDF]

, 2014
Background: Regular monitoring of patient progress is important to assess the clinical effectiveness of an intervention. Recently, initiatives within UK child and adolescent mental health services (CAMHS) have advocated the use of session-by-session ...
Marriott, Michael, Goodman, R, Taylor, J, Newell, Karen, Taylor, John, Hall, Charlotte L., Moldavsky, Maria, Charlotte L Hall, Pass, S, Hollis, Chris, Karen Newell, Hall, CL, Hollis, C, Maria Moldavsky, Robert Goodman, Chris Hollis, Moldavsky, M, Sayal, K, Newell, K, Sarah Pass, John Taylor, Kapil Sayal, Sayal, Kapil, Marriott, M, Goodman, Robert, Michael Marriott, Pass, Sarah   +26 more
core   +1 more source

Estudo das mudanças percebidas em usuários de Centros de Atenção Psicossocial do Sul do Brasil a partir de sua inserção nos serviços

Saúde em Debate
RESUMO Objetivou-se identificar as mudanças percebidas por 1.597 usuários de 40 Centros de Atenção Psicossocial do Sul do Brasil, utilizando-se a Escala de Mudança Percebida - Pacientes. Na avaliação global da escala, foi evidenciada melhora em 84,9% dos
Uiasser Thomas Franzmann, Luciane Prado Kantorski, Vanda Maria da Rosa Jardim, Carlos Alberto dos Santos Treichel   +3 more
doaj   +1 more source

The short-term effect on alliance and satisfaction of using patient feedback scales in mental health out-patient treatment. A randomised controlled trial

BMC Health Services Research, 2012
Background The main aim was to investigate the effect of using two brief feedback scales in mental health out-patient treatment six weeks after starting treatment, compared to treatment as usual.
Rise Marit, Eriksen Lasse, Grimstad Hilde, Steinsbekk Aslak   +3 more
doaj   +1 more source