Results 211 to 220 of about 3,885,737 (351)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Novel way of displaying Delphi responses when collecting through the REDCap data collection system. [PDF]

Trials
Barber VS, Calvert C, Appelbe DE.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Tracking public health, utilization and outcomes during a pandemic using monitoring surveys. [PDF]

BMC Public Health
Boyle J, Brassell T, Iachan R, Kinder R, ZuWallack R, Dayton J.   +5 more
europepmc   +1 more source

Provision of NHS generalist and specialist services to care homes in England: review of surveys

Primary Health Care Research & Development, 2015
S. Iliffe, S. Davies, A. Gordon, J. Schneider, T. Dening, C. Bowman, H. Gage, F. Martin, J. Gladman, C. Victor, Julienne Meyer, C. Goodman   +11 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strengthening Care for Children Using a Virtual Integrated General Practitioner-Pediatrician Model of Primary Care (SUSTAIN): Protocol for a Stepped Wedge Cluster Randomized Controlled Trial.

JMIR Res Protoc
Meyers Morris T, Hiscock H, Wheeler K, Miller C, Hu N, Hassan Shire S, Crespo-Gonzalez C, Bullock S, Taylor N, Boyle D, Sanci L, Lawson K, Adams L, Peacock K, Hodgins M, Christie A, Lingam R.   +16 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Education-Based Inequality in Edentulism and Functional Dentition Among Older Brazilian Adults: A Study Covering a Period of 20 Years. [PDF]

Int J Dent
Fonseca MLV, Gomes VE, Chamane LS, da Cruz CAG, Silva MLDN, Francisco ALG, Chalub LLFH, Ferreira RC.   +7 more
europepmc   +1 more source