Results 91 to 100 of about 26,804,747 (294)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Health Care that Works for All Americans
, 2006 Congress authorized the Citizen’s Health Care Working Group as a provision of the Medicare Prescription Drug, Improvement, and Modernization Act Of 2003. This provision was sponsored by Senators Ron Wyden of Oregon and Orrin Hatch of Utah. The mission of
Citizens' Health Care Working Group
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
South African Journal of Industrial Engineering, 2012 South Africa has tried various strategies to improve access, quality and cost-efficiency in the health care delivery systems. However it is clear that the optimal approach has yet to be found. It has been recognised that health technology is an important
M.O. Kachieng’a
doaj
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Information technology strategy and alignment issues in health care organizations
, 2013 Background: Information technology (IT) plays a key role in public health care management because it could improve quality, efficiency, and patient care.
Fryk, Pontus, +4 more
core +1 more source
Neuropsychiatric Disease and Treatment, 2018 Erin Falconer,1 David Kho,1 John P Docherty2 1ODH, Inc., Princeton, NJ, USA; 2Otsuka America Pharmaceutical, Inc., Princeton, NJ, USA Abstract: This systematic literature review investigates the use of technology for the coordination and management of ...
Falconer E, Kho D, Docherty JP
doaj
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source