Results 231 to 240 of about 12,844,046 (357)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
History of the taxonomy of <i>Acinetobacter</i>: the emergence of hospital-adapted species of global health concern. [PDF]
Karah N, Nemec A, Uhlin BE.
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Self-Medication as a Global Health Concern: Overview of Practices and Associated Factors-A Narrative Review. [PDF]
Aljinović-Vučić V.
europepmc +1 more source
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Sodium Content and Label Discrepancies in Processed and Ultra-Processed Foods in Bangladesh: A Public Health Concern. [PDF]
Afroza U +7 more
europepmc +1 more source
Vaping: A growing global health concern
A. Besaratinia, S. Tommasi
semanticscholar +1 more source
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Unveiling the link between Oropouche virus and Guillain-Barré syndrome: a growing public health concern. [PDF]
Agrawal A +6 more
europepmc +1 more source

