Results 91 to 100 of about 299,746 (312)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Community health councils [PDF]

BMJ, 1980
openaire   +5 more sources

CONSTRUCTION OF SOCIAL CONTROL IN THE MUNICIPALITY OF FAIR SANTANA - BAHIA: THE DECENTRALIZATION PROCESS [PDF]

Revista Gestão & Saúde, 2014
The recognition of Brazil as a citizen tends to open spaces for democratic construction, so that with this organizing principle of society shall participate effectively in state actions.
Paulo Roberto Lima Falcão do Vale, Ozemária da Silva Oliveira, Waldson Nunes de Jesus, Adroaldo dos Santos, Maricélia Maia de Lima   +4 more
doaj  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Social determinants of health and local government: understanding and uptake of ideas in two Australian states

Australian and New Zealand Journal of Public Health, 2017
Objective: To examine the awareness and perceptions of local government staff about the social determinants of health (SDoH) and health inequity and use of these ideas to shape policy and practice.
Angela Lawless, Anna Lane, Felicity‐ann Lewis, Fran Baum, Patrick Harris   +4 more
doaj   +1 more source

Changes in the proportion of facility-based deliveries and related maternal health services among the poor in rural Jhang, Pakistan: results from a demand-side financing intervention

International Journal for Equity in Health, 2011
Background Demand-side financing projects are now being implemented in many developing countries, yet evidence showing that they reach the poor is scanty.
Agha Sohail
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Working Partnership USA: The Latest Initiative for a Council On the Cutting Edge [PDF]

, 1996
[Excerpt] Inject a dose of innovation and a lot of hard work, and there are over 600 local labor councils across the United States which can be jumpstarted to play pivotal roles in labor\u27s rebirth.
Dean, Amy B.
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Plenária Virtual Permanente: em busca da interlocução entre os conselhos de saúde

Ciência da Informação, 2008
A Plenária Virtual Permanente é um sistema de áudio e vídeo para redes digitais desenvolvido para conselhos de saúde do Brasil. O artigo aborda as discussões que subsidiaram a criação do dispositivo, a descrição do mesmo e os desafios para a inclusão ...
Angélica Baptista Silva, Eliana Labra
doaj