Results 71 to 80 of about 202,216 (259)

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Neighborhood Environment and Poor Maternal Glycemic Control–Associated Complications of Gestational Diabetes Mellitus

AJPM Focus
Introduction: Risk of complications due to gestational diabetes mellitus is increasing in the U.S., particularly among individuals from racial minorities.
Leela V. Thomas, PhD, Claudine T. Jurkovitz, MD, MPH, Zugui Zhang, PhD, FAHA, Mitchell R. Fawcett, MBA, M. James Lenhard, MD, FACP, FACE   +4 more
doaj   +1 more source

Geographical Variations in the Clinical Management of Colorectal Cancer in Australia: A Systematic Review

Frontiers in Oncology, 2018
BackgroundIn Australia, cancer survival is significantly lower in non-metropolitan compared to metropolitan areas. Our objective was to evaluate the evidence on geographical variations in the clinical management and treatment of colorectal cancer (CRC ...
Fiona Crawford-Williams, Fiona Crawford-Williams, Sonja March, Sonja March, Michael J. Ireland, Michael J. Ireland, Arlen Rowe, Arlen Rowe, Belinda Goodwin, Belinda Goodwin, Melissa K. Hyde, Melissa K. Hyde, Suzanne K. Chambers, Suzanne K. Chambers, Suzanne K. Chambers, Suzanne K. Chambers, Suzanne K. Chambers, Joanne F. Aitken, Joanne F. Aitken, Joanne F. Aitken, Joanne F. Aitken, Jeff Dunn, Jeff Dunn, Jeff Dunn, Jeff Dunn   +24 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Rethinking 15-min walkable neighborhoods for healthy aging: evidence from cardiovascular health in Shanghai’s older adults

Frontiers in Public Health
Interventions targeting chronic diseases through urban built environments have gained increasing attention due to their potential population-level health benefits.
Cui Wu, XingZhao Liu, Yanting Xu, Yanting Xu, Yang Meng, Jing Wu   +5 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Geographical inequalities and temporal trends in pediatric cardiovascular diseases in Indonesia: a 34-year global burden of disease analysis

Frontiers in Public Health
BackgroundPediatric cardiovascular diseases (CVDs), including congenital heart anomalies (CHAs), rheumatic heart disease (RHD), and related conditions, remain a significant health challenge in Indonesia, especially given the country’s diverse geography ...
Muhammad Iqhrammullah, Derren D. C. H. Rampengan, Ikhwan Amri, Roy Novri Ramadhan, Muhammad Haneef Ghifari, Firyal Khansa, Novi Kurnia Rizki, Starry H. Rampengan, Radityo Prakoso, Muhammad Habiburrahman, Muhammad Habiburrahman   +10 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source