Results 111 to 120 of about 20,751,393 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Polish Society's Perspective on the Challenges Related to Childhood Cancer: Analysis of Public Opinion Research in Poland

Cancer Reports
Background Treatment of children diagnosed with cancer requires coordinated, multimodal therapy that is often resource intensive and can occur over several years.
J. Pruban, K. Maleszewska, J. Antoniuk‐Majchrzak, M. Wujec, M. Czerwińska, P. Jurowczyk, Ł. Zieliński, A. Raciborska   +7 more
doaj   +1 more source

Health education in colleges

, 1945
On cover: Issued jointly by L.W. Brooks, State Superintendent of Public Instruction, F.C. Beelman, M.D. Secretary and Executive Officer, Kansas State Board of Health.; "A companion publication to this report, called Health Education in Elementary and ...
Kansas. State Policy-Making Committee on Health Education.
core  

Sexual health education knowledge required by health education teachers in Finland

Health education teachers have a crucial role to play in delivering sexual health education in schools, with their own knowledge being key to providing comprehensive sexual health education to adolescents.
Jämiä, Lotta, Kylmä, Jari, Haavisto, Elina   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Resources and Strategies to Build Vaccine Confidence among Adults

EDIS
As Extension continues to expand its purview in adult immunization education, it should provide strategies for communicating one-on-one and in smaller and larger groups, as well as links to resources to build confidence and promote access for adults who
Kathryn A. Stofer, Alissa V. Katsaras, Skye Dougan, Miranda Jones, LaToya J. O'Neal   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Community-based education of health personnel : report of a WHO study group [meeting held in Geneva from 4 to 6 November 1985]

, 1987
ita published by: Milan : Fondazione Smith Kline89 p.A detailed explanation of the meaning of community-based education, including its objectives, conceptual foundations, and relationship to current theories of education and methods of teaching.
World Health Organization, WHO Study Group on Community-Based Education of Health Personnel   +1 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source