Results 141 to 150 of about 6,730,818 (347)

Kidney Health for All: Bridging the Gap in Kidney Health Education and Literacy

open access: yesTurkish Journal of Nephrology, 2022
Robyn G. Langham   +12 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Programa de educação pelo trabalho para a saúde nas escolas: oficina sobre sexualidade

open access: yesRevista Brasileira de Educação Médica
Este artigo relata uma experiência de educação em saúde sobre sexualidade, conduzida por monitores do PET-Saúde, da Universidade de Brasília, do subgrupo de Planejamento Familiar.
Ariel Sousa Neto   +5 more
doaj   +1 more source

Creating a center for global health at the University of Wisconsin-Madison. [PDF]

open access: yes, 2008
Globalization, migration, and widespread health disparities call for interdisciplinary approaches to improve health care at home and abroad. Health professions students are pursuing study abroad in increasing numbers, and universities are responding with
Baumann, Linda   +7 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Education, Information, and Improved Health: Evidence from Breast Cancer Screening [PDF]

open access: yes
While it is well known that education strongly predicts health, less is known as to why. One reason might be that education improves health-care decision making.
Chen, Keith, Lange, Fabian
core  

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