Results 141 to 150 of about 13,037,600 (316)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Ser mulher e participar de grupo educativo em saúde na comunidade: motivações e expectativas [Being a woman and taking part in a communityhealth educational group: motivations and expectations]

open access: yesRevista Enfermagem UERJ, 2014
RESUMO: Este estudo objetiva compreender o significado de ser mulher na sociedade atual, conhecer a concepção de saúde e identificar as motivações e expectativas de mulheres da comunidade sobre sua participação em um grupo educativo.
Joyce Mazza Nunes   +4 more
doaj  

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

Demandas de autocuidado em grupo terapêutico: educação em saúde com usuários de substâncias psicoativas [Demands for self-care in therapeutic group: health education with users of psychoactive substances]

open access: yesRevista Enfermagem UERJ, 2013
Objetivou-se compreender as contribuições do Grupo Terapêutico Educação em Saúde para a identificação das demandas terapêuticas de autocuidado entre usuários de substâncias psicoativas.
Selene Cordeiro Vasconcelos   +5 more
doaj  

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