Results 71 to 80 of about 6,749,359 (294)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Drama as a method of health education: the case of project “Health Steps”

Annales Academiae Medicae Silesiensis
The study describes pedagogical activities undertaken in “Health Steps – education and learning as a determinant of a healthy and open society” project, focusing on the applied drama method, and outlines the conclusions from the evaluation among teachers
Marcin Drzazga, Tomasz Wojtasik
doaj   +1 more source

Community Health Workers: A Holistic Solution for Individual and Community Health [PDF]

, 2012
Community Health Workers (CHWs) go by many names, including outreach workers, patient navigators, peer health educators, and lay health advocates. CHWs help people overcome obstacles by accompanying them through treatment, monitoring needs for food and ...
Magavern, Sam, MacKeller, Jacqueline, Bauer Walker, Jessica   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Impact of an interprofessional oral health education program on health care professional and practice behaviors: a RE-AIM analysis

Pediatric Health, Medicine and Therapeutics, 2015
Patricia A Braun,1 Katina Widmer Racich,1 Sarah B Ling,2 Misoo C Ellison,3 Karen Savoie,4 Linda Reiner,5 John M Westfall41University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 2Department of Family Medicine, Broadlawns Medical Center, Des ...
Braun PA, Widmer Racich K, Ling SB, Ellison MC, Savoie K, Reiner L, Westfall JM   +6 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Sheepskin or Prozac: The Causal Effect of Education on Mental Health [PDF]

Mental illness is associated with large costs to individuals and society. Education improves various health outcomes but little work has been done on mental illness.
Arnaud Chevalier, Leon Feinstein
core  

Perbedaan Tingkat Kecemasan Menghadapi Menarche Sebelum Dan Sesudah Diberikan Pendidikan Kesehatan Pada Siswi Kelas Vii Di Smp Negeri 46 Palembang [PDF]

, 2019
Background : Menarche is first menstruation experienced by teenagers aged 10- 16 and occurs in the mid period toward puberty phase. At this age, it is necessary for the teenagers to gain health education about Menarche so that the teenagers especially ...
Nita, Kadek
core