Results 81 to 90 of about 6,749,359 (294)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Pediatrics and Neonatology, 2013 The effectiveness of education programs for pediatric patients receiving oral antibiotic suspension was unclear. Methods: When pediatric patients were prescribed antibiotics in powder form for suspension at the outpatient clinic of a university hospital,
Hsin Hu +5 more
doaj +1 more source
Healthy and health promoting colleges - an evidence base [PDF]
, 2008 A report from a study which aimed to identify sources of evidence about existing initiatives which aim to promote physical and emotional health and well-being of young people (aged 14-19) within further education settings in England (or comparable ...
Aggleton, Peter +2 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Health/education telecommunications experiment [PDF]
The use of ATS 6 spacecraft in a general telecommunication link for the health/education experiment demonstrates the feasibility of the small receiver-only terminal consisting of a ten foot diameter antenna located on a three-legged mount.
Whalen, A. A.
core +1 more source
Benefits of interprofessional education in health care. [PDF]
, 2007 This article examines some of the literature regarding the benefits of interprofessional education (IPE) in the field of health care. These benefits in relation to service users (and carers), higher education institutions, service providers and students ...
Chelvanayagam, Sonya, Illingworth, P.
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source