Results 111 to 120 of about 3,040,148 (317)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Community Health Evaluation in Normanton [PDF]

, 2008
The Community Health research project was based in the Normanton Neighbourhood Renewal area of Derby. It involved five key parties; the Derby City Partnership, Derby City Primary Care Trust, the Derby City Council Environmental Health and Trading ...
Bowes, L., Christopoulos, M., Subhra, G., Jeffels, S., Richards, L., Hutchinson, J.   +5 more
core  

Impacto de las acciones para la eliminación sostenible de la deficiencia de yodo en Cuba

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos: Evaluar la efectividad del “Programa de Eliminación Sostenible de Deficiencia de Yodo” mediante determinación de yoduria y prevalencia de bocio. Materiales y métodos.
C. Blanca Terry-Berro, Ibrahim Quintana-Jardines, Maytell de la Paz-Luna, Julieta García, Raúl Fernández-Bohórquez, Denise Silvera-Téllez, Yoandry Díaz-Fuentes, Ana Ferret-Martínez, Denia Reyes-Fernández   +8 more
doaj  

Dynamic Health Evaluation Method for Metro Communication System Based on Random Forests Algorithm

Chengshi guidao jiaotong yanjiu
Objective The health of metro communication system has a direct bearing on the efficiency and safety of metro operation. In view of the problems such as one-sided evaluation results and subjective evaluation criteria in current health evaluation method ...
LI Sanjiang, JIANG Zhilin, LIN Yiwei, LU Huaike, GONG Yongjun   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Young Women's Sexual Health Project : evaluation report

, 2003
Due to an increase in the rate of heterosexually acquired HIV in young women in the NT over the past five to 10 years, the DHCS decided in early 2001 to develop a strategic approach to early intervention to prevent further cases of heterosexually ...

core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Fuzzy Decision-Making Approach to the Health Assessment and Optimization of Architecture-Dominated Outdoor Spaces in High-Density Urban Environments

Buildings
As urbanization rapidly increases, the design of outdoor spaces in high-density urban environments has become crucial for promoting public health. This study investigates the health impacts of architecture-dominated outdoor spaces, particularly focusing ...
Yanyan Huang, Yi Yang, Kangwei Tu, Tiancheng Yang   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source