Results 131 to 140 of about 3,040,148 (317)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Community health program evaluation report : October 1993 to June 1997

open access: yes, 1997
Evaluation Report of the Community Health Program undertaken in response to the requirements of the Financial Management Act 1995 and Treasurer's Directions 3.4.
Community Health Program Review Team
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Role of health education in promoting health in Libya: Evaluation of the existing situation and assessment of future needs

open access: yes, 2000
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A variety of programmes of health education are designed, addressing promotion of health of the Libyan community.
Elfituri, Abdulbaset Ali
core  

Landscape Pattern Evolution–Informed Ecosystem Health Assessment and Restoration Strategies in the Luxi River Basin (Chengdu, China) Based on the PSR Framework

open access: yesLand
Assessing ecosystem health in rapidly urbanizing watersheds requires policy-relevant and empirically grounded indicator systems. Focusing on the Luxi River Basin in Chengdu’s Tianfu New Area, this study develops an ecosystem health evaluation and ...
Yi Chen, Guochao Li, Yixin Hao
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A confiabilidade dos dados nos formulários de Autorização de Internação Hospitalar (AIH), Rio de Janeiro, Brasil

open access: yesCadernos de Saúde Pública
Apresenta-se neste artigo um estudo sobre a qualidade das informações contidas no banco constituído por dados dos formulários de Autorização Hospitalar (AIH). O formulário AIH é um documento do Sistema Único de Saúde (SUS) preenchido pelos hospitais para
Claudia Maria T. Veras   +1 more
doaj  

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