Results 61 to 70 of about 7,581,927 (400)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Disease and economic burden for rare diseases in Taiwan: A longitudinal study using Taiwan's National Health Insurance Research Database. [PDF]

PLoS ONE, 2018
BACKGROUND:High-cost orphan drugs are becoming increasingly available to treat rare diseases that affect a relatively small population. Little attention has been given to the prevalence of rare diseases and their health-related economic burden in Taiwan.
Jason C Hsu, Huai-Chueh Wu, Wen-Chia Feng, Chih-Ho Chou, Edward Chia-Cheng Lai, Christine Y Lu   +5 more
doaj   +1 more source

State-Level and County-Level Estimates of Health Care Costs Associated with Food Insecurity. [PDF]

, 2019
IntroductionFood insecurity, or uncertain access to food because of limited financial resources, is associated with higher health care expenditures. However, both food insecurity prevalence and health care spending vary widely in the United States.
Basu, Sanjay, Berkowitz, Seth A, Gundersen, Craig, Seligman, Hilary K   +3 more
core  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Health Expenditure Scenarios in the New Member States – Comparative Report on Bulgaria, Estonia, Hungary, Poland and Slovakia. ENEPRI Research Reports No. 43, 19 December 2007 [PDF]

, 2007
The objective of this comparative report is to present the model of future health care system revenues and expenditures in selected Central and Eastern European countries which are now the new EU member states, and to discuss projection assumptions and ...
Golinowska, Stanislawa, Kocot, Ewa, Sowa, Agnieszka.   +2 more
core  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Effects of expanding a non-contributory health insurance scheme on out-of-pocket healthcare spending by the poor in Turkey

BMJ Global Health, 2019
Introduction Insufficient or no health insurance creates financial access barriers to healthcare services, especially for vulnerable populations. The Green Card scheme, a non-contributory government-funded health insurance scheme for the poor in Turkey ...
Rifat Atun, Abdullah Tirgil, William T Dickens   +2 more
doaj   +1 more source

Aging populations and expenditures on health

The Journal of the Economics of Ageing
Aging populations exert upwards pressure on healthcare systems, raising concerns about increasing expenditures on health. This paper reviews the empirical literature on the issue and critically assesses the strengths and weaknesses of the outcomes measured, methodologies used, and the hypotheses tested.
Malene Kallestrup-Lamb, Alexander O.K. Marin, Seetha Menon, Jes Søgaard   +3 more
openaire   +4 more sources

Health Expenditure and Income in the United States [PDF]

SSRN Electronic Journal, 2007
AbstractThis paper investigates the long‐run economic relationship between health care expenditure and income in the US at a State level. Using a panel of 49 US States over the period 1980–2004, we study the non‐stationarity and co‐integration between health spending and income, ultimately measuring income elasticity of health care.
Moscone F, Tosetti E
openaire   +6 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source