Results 61 to 70 of about 7,980,845 (406)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Measuring financial protection against catastrophic health expenditures: methodological challenges for global monitoring

International Journal for Equity in Health, 2018
BackgroundMonitoring financial protection against catastrophic health expenditures is important to understand how health financing arrangements in a country protect its population against high costs associated with accessing health services.
J. Hsu, Gabriela Flores, David K. Evans, A. Mills, K. Hanson   +4 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Relationship Between Median Age and Death Cases During the Coronavirus Disease 2019 (COVID-19) Pandemic: The Mediating Role of Current Health Expenditure

Bezmiâlem Science, 2020
Objective:This study aimed to identify and define the relationships among the median ages of countries, their death cases, and current health expenditures [percentage (%) of gross domestic product (GDP)] during the Coronavirus disease 2019 (COVID-19 ...
Kerem TOKER, Zekiye İrem GÖZÜBOL
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Iranian Household Financial Protection against Catastrophic Health Care Expenditures [PDF]

Iranian Journal of Public Health, 2012
Background: Protecting households against financial risks is one of objectives of any health system. In this regard, Iran's fourth five year developmental plan act in its 90th article, articulated decreasing household's exposure to catastrophic health ...
M Nekoei Moghadam, M Banshi, M Akbari Javar, M Amiresmaili, S Ganjavi   +4 more
doaj   +1 more source

Health care expenditures among long-term survivors of pediatric solid tumors: Results from the French Childhood Cancer Survivor Study (FCCSS) and the French network of cancer registries (FRANCIM).

PLoS ONE, 2022
BackgroundChildhood cancer survivors (CCS) may require lifelong medical care due to late effects of cancer treatments. Little is known about of their healthcare utilization and expenditures at long-term especially in publicly funded health care system ...
Daniel Bejarano-Quisoboni, Nathalie Pelletier-Fleury, Rodrigue S Allodji, Brigitte Lacour, Pascale GrosClaude, FRANCIM Group, Hélène Pacquement, François Doz, Delphine Berchery, Claire Pluchart, Piere-Yves Bondiau, Julie Nys, Angela Jackson, Charlotte Demoor-Goldschmidt, Agnès Dumas, Cécile Thomas-Teinturier, Giao Vu-Bezin, Dominique Valteau-Couanet, Nadia Haddy, Brice Fresneau, Florent de Vathaire   +20 more
doaj   +1 more source

AGE, HEALTH AND MEDICAL EXPENDITURE [PDF]

, 2001
Ageing populations in developed countries have placed increasing demands on health care services and drawn attention to how age is related to medical expenditure. The effect of ageing on health involves a mixture of biological and social factors that ideally requires an interdisciplinary approach if it is to be properly understood.
openaire   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Rare Disease Curative Care Expenditure- Financing Scheme-Health Provider- Beneficiary Group Analysis — An Empirical Study in Sichuan Province, China [PDF]

, 2021
Jia Li, Lian Yang, Yitong Zhang, Hailun Liao, Yuan Ma, Qun Sun   +5 more
openalex   +1 more source