Results 51 to 60 of about 259,125 (260)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The role of the hospital in a changing environment

Bulletin of the World Health Organization, 2000
Hospitals pose many challenges to those undertaking reform of health care systems. This paper examines the evolving role of the hospital within the health care system in industrialized countries and explores the evidence on which policy-makers might base
Martin McKee, Judith Healy
doaj  

Drinking water, sanitation, hygiene, and health conditions in India: Findings from the national sample survey

Journal of Family Medicine and Primary Care
Introduction: Uncertainty exists in the drinking water, sanitation, hygiene, and health conditions due to mosquitoes and flies across India. Therefore, this study aimed to assess the availability of drinking water, sanitation, hygiene, and health in ...
Vishal Vennu
doaj   +1 more source

National ignition facility environment, safety, and health management plan [PDF]

, 1995
The ES&H Management Plan describes all of the environmental, safety, and health evaluations and reviews that must be carried out in support of the implementation of the National Ignition Facility (NIF) Project. It describes the policy, organizational responsibilities and interfaces, activities, and ES&H documents that will be prepared by the Laboratory
openaire   +2 more sources

Does health facility service environment matter for the receipt of essential newborn care? Linking health facility and household survey data in Malawi

Journal of Global Health, 2017
Health facility service environment is an important factor for newborns survival and well-being in general and in particular in high mortality settings such as Malawi where despite high coverage of essential interventions, neonatal mortality remains high.
Carvajal–Aguirre, Liliana, Mehra, Vrinda, Amouzou, Agbessi, Khan, Shane M, Vaz, Lara, Guenther, Tanya, Kalino, Maggie, Zaka, Nabila   +7 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PREVALENCE AND HEALTH FACILITY FACTORS ASSOCIATED WITH ABNORMAL VAGINAL DISCHARGE AMONG PREGNANT WOMEN ATTENDING ANTENATAL CARE AT WAKISO HEALTH CENTER IV, WAKISO DISTRICT – A CROSS-SECTIONAL STUDY.

Student's Journal of Health Research Africa
Introduction Abnormal vaginal discharge (AVD) increases the risk of sexually transmitted infections (STIs) and adverse pregnancy outcomes. This study purposed to determine the prevalence and health facility factors associated with abnormal vaginal ...
Martin Muyomba , Namaasa Aeron Mukirya
doaj   +1 more source

The design of a wireless solar-powered router for rural environments isolated from health facilities

IEEE Wireless Communications, 2008
Isolated rural areas often lack terrestrial telecommunication networks, especially in developing countries, which poses an important obstacle for offering health assistance of acceptable quality. On the other hand, low density and low concentration of population, lack of electricity in many areas, and accessibility problems make it difficult to ...
Francisco-Javier Simó-Reigadas, Andrés Martínez-Fernández, Pablo Osuna García, Silvia Lafuente Sanz, Joaquín Seoane Pascual   +4 more
openaire   +2 more sources