Results 131 to 140 of about 684,204 (318)

Health Care Financing Reform: Issues and Updates [PDF]

open access: yes
Generation of funds and its efficient utilization have remained as a challenge to health authorities. This issue presents the recent efforts on health care financing as well as the concerns regarding its coverage, efficiency and sustainability.
Health Policy Development Staff (DOH)
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Out-of-pocket cost and financial catastrophe of patients with cancer: the alarming cost-of-illness in Bangladesh

open access: yesInternational Journal for Equity in Health
Background Out-of-pocket (OOP) cost of cancer treatment has increased substantially globally. In low- and middle-income countries, many patients face financial distress due to cancer.
Abdur Razzaque Sarker   +2 more
doaj   +1 more source

Breaking the Mortality Curve: Investment-Driven Acceleration in Life Expectancy and Insurance Innovation

open access: yesRisks
Capital investment in longevity science—research targeting the biological processes of aging through interventions like cellular reprogramming, AI-driven drug discovery, and biological age monitoring—may create significant divergence between traditional ...
David M. Dror
doaj   +1 more source

The Sustainable Development Goals: One-Health in the World’s Development Agenda [PDF]

open access: yes, 2015
The Sustainable Development Goals (SDGs), adopted by the UN General Assembly in September 2015, embody a One-Health strategy—healthy people living on a habitable planet. Extending beyond the social development emphasis of the Millennium Development Goals
Friedman, Eric A., Gostin, Lawrence O.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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