Results 191 to 200 of about 118,473 (313)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Minutes of the Health Care Facilities Financing Authority - April 15, 2024

open access: yes
Downloaded from: https://www.nj.gov/njhcffa/meeting/minutes/index ...
New Jersey. Health Care Facilities Financing Authority
core  

174:oral Paving the road for the institutionalization of a national priority setting mechanism to advance UHC

open access: yesBMJ Global Health, 2022
Kahsu Bekuretsion   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Minutes of the Health Care Facilities Financing Authority - Special Meeting - August 2, 2024

open access: yes
Downloaded from: https://www.nj.gov/njhcffa/meeting/minutes/index ...
New Jersey. Health Care Facilities Financing Authority
core  

Health systems performance in health outcomes, health financing and COVID-19 pandemic: Lessons from 31 countries. [PDF]

open access: yesPLoS One
Kolivand P   +13 more
europepmc   +1 more source

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