Results 201 to 210 of about 685,929 (311)

Health systems performance in health outcomes, health financing and COVID-19 pandemic: Lessons from 31 countries. [PDF]

PLoS One
Kolivand P, Arabloo J, Saberian P, Dorooudi T, Rajaie S, Karimi F, Raei B, Behzadifar M, Parvari A, Ehsanzadeh SJ, Homayoun S, Salehbeigi S, Namdar P, Azari S.   +13 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Linking Health Financing to Oral Health Coverage and Disease Burden in SEARO Countries: A Cross-Sectional Analysis of Country Level Data. [PDF]

Int J Health Plann Manage
Acharya S, Mathur MR, Tadakamadla SK, Brand A.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Implications of U.S. withdrawal from the World Health Organization on health financing in Africa. [PDF]

Health Policy Open
Sokunbi TO, Umar AB, Eyo UB.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tobacco control in the Sustainable Development Goals: a precarious inclusion?

The Lancet Public Health, 2017
Roy Small, Natalia Linou, Douglas Webb, Mandeep Dhaliwal   +3 more
doaj   +1 more source

Public health financing in Brazil (2019-2022): an analysis of the national health fund and implications for health management. [PDF]

Front Public Health
Nunes Marinho L, Campbell SM, da S T Amaral IB, Reis E Silva R, Godman B, Meyer JC, Godói IPD.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Providing financial protection in health for low-income populations: a comparison of health financing designs in East Asia. [PDF]

Int J Equity Health
Zhang Q, Wang JS, He AJ, Peng C, Abe A, Ku I, Ng IYH, Zhao X.   +7 more
europepmc   +1 more source