Results 21 to 30 of about 556,257 (242)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Data analytics based positioning of health informatics programs [PDF]

, 2017
The Master of Science in Computer Information Systems (CIS) with concentration in Health Informatics (HI) at Metropolitan College (MET), Boston University (BU), is a 40-credit degree program that are delivered in three formats: face-to-face, online, and ...
Brusic, Vladimir, Chitkushev, Lou, Zhang, Guanglan   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The CHIME graduate programme in health informatics [PDF]

, 2003
In 1999 University College London inaugurated a programme of graduate part-time Health Informatics courses to support the UK National Health Service?s Information for Health strategy.
Darlison, MW, Ingram, D, Murphy, J, Taylor, P   +3 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

One health informatics

Proceedings of the 23rd International Conference on World Wide Web, 2014
Zoonoses are a class of infectious diseases causing growing concern of health authorities worldwide. Human and economic costs of zoonoses are substantial, especially in low-resource countries. New zoonoses emerge as a consequence of ecological, demographic, cultural, social and behavioral factors.
openaire   +2 more sources

The IM&T training needs of doctors in an acute UK NHS trust [PDF]

, 2003
Advanced information systems are seen as a key factor in plans to modernise the delivery of healthcare. In the UK, the General Medical Council and the Information Authority have stressed the need for doctors to possess not just IT skills, but more ...
Devvit, N, Murphy, J
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Information architecture for a federated health record server [PDF]

, 2002
This paper describes the information models that have been used to implement a federated health record server and to deploy it in a live clinical setting.
Austin, T, Ingram, D, Kalra, D, Lloyd, D, O'Connor, A, Patterson, D   +5 more
core  

Disparities in registration and use of an online patient portal among older adults: findings from the LitCog cohort [PDF]

, 2015
(C) The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved.Financial disclosure: This project was supported by the National Institute on Aging (R01 AG030611), the National ...
Alsabbagh, Ancker, Bailey, Baker, Bender, Berkman, Blumenthal, Cho, Chrischilles, Eklund, Goel, Goel, Goldzweig, Haggstrom, Hsiao, Jung, Krist, Laura M Curtis, Levine, Lyles, Maat, Mayberry, Michael S Wolf, Mishuris, Mita Sanghavi Goel, Mossberger, Norman, Osborn, Paasche-Orlow, Pandey, Rachel O’Conor, Ralston, Samuel G Smith, Sarkar, Sarkar, Sarkar, Smith, Tang, Tom, Turvey, Viswanath, Wade-Vuturo, Wallston, Weiss, Weppner, William Aitken, Wolf, Zell, Zhang, Zickmund   +49 more
core   +1 more source