Results 71 to 80 of about 243,126 (285)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The characteristics and motivations of online health information seekers : cross-sectional survey and qualitative interview study [PDF]
, 2011 Background: Most households in the United Kingdom have Internet access, and health-related Internet use is increasing. The National Health Service (NHS) Direct website is the major UK provider of online health information.
Inglis, Nadia +10 more
core +1 more source
Design and Developing of Health Information Behavior Questionnaire [PDF]
پیاورد سلامتBackground and Aim: The term “information behavior,” with an emphasis on health and hygiene, refers to purposeful actions taken to satisfy informational needs related to health.
Shahnaz Khademizadeh +2 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
مدیریت اطلاعات سلامت, 2019 Introduction: Although several studies have been conducted on online health information seeking behavior and its relationship with health beliefs, there are still gaps in identifying the exact and comprehensive relationships of these factors in Iran. The
Fatima Baji +2 more
doaj +1 more source
Health Information–Seeking Behaviors of Family Caregivers: Analysis of the Health Information National Trends Survey [PDF]
JMIR Aging, 2019 The growing population of aging adults relies on informal caregivers to help meet their health care needs, get help with decision making, and gather health information.The objective of this study was to examine health information-seeking behaviors among caregivers and to identify caregiver characteristics that contribute to difficulty in seeking health
Lauren R Bangerter +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
, 2020 For college students, mental health is an important factor in ensuring their ability to study and have a normal life. This research focuses on factors affecting the mental health of college students in the information network society.
Dongxiao Gu +4 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The role of community-based, problem-centered information intermediaries in local problem solving [PDF]
, 2006 Lobbying for school reform, cleaning up graffiti, and enacting noise ordinances are daily problem-based activities performed by organized citizen groups.
Souden, Maria L. +5 more
core +1 more source