Results 81 to 90 of about 445,340 (275)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Health Information–Seeking Behavior of Seniors Who Use the Internet: A Survey

Journal of Medical Internet Research, 2015
The Internet is viewed as an important source for health information and a medium for patient empowerment. However, little is known about how seniors use the Internet in relation to other sources for health information.The aim was to determine which information resources seniors who use the Internet use and trust for health information, which sources ...
Medlock, Stephanie, Eslami, Saeid, Askari, Marjan, Arts, Derk L., Sent, Danielle, de Rooij, Sophia E., Abu-Hanna, Ameen   +6 more
openaire   +5 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Role of Public Libraries on Kerman Health Information Seeking Behavior

مجله انفورماتیک سلامت و زیست پزشکی, 2016
Introduction: Health clients when seeking health information are faced with challenges such as complexity of the health system, increase in prevalence of chronic diseases, need to participate in the health care, and increase in the available information ...
Maryam Okhovati, Elham Sharifpoor, Mehran Hamzeh Zadeh, Masoomeh Shahsavari, Mahdieh Soltan shahi   +4 more
doaj  

Information-seeking behavior on sexually transmitted infections and its associated factors among university students in Ethiopia: a cross-sectional study

Reproductive Health, 2022
Plain language summary Sexually Transmitted Infections (STIs) are infections commonly spread through sexual contact and transmitted by bacteria, viruses, or parasites and are the most common cause of illness among university students. Information-seeking
Aynadis Worku Shimie, Kassahun Dessie Gashu, Atsede Mazengia Shiferaw, Shegaw Anagaw Mengiste   +3 more
doaj   +1 more source

Health Information–Seeking Behaviors of Family Caregivers: Analysis of the Health Information National Trends Survey [PDF]

JMIR Aging, 2019
The growing population of aging adults relies on informal caregivers to help meet their health care needs, get help with decision making, and gather health information.The objective of this study was to examine health information-seeking behaviors among caregivers and to identify caregiver characteristics that contribute to difficulty in seeking health
Lauren R Bangerter, Joan Griffin, Kristin Harden, Lila J Rutten   +3 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Investigation of Online Health Information Seeking Behavior among University Students in Ahvaz City, Iran

مدیریت اطلاعات سلامت, 2019
Introduction: Although several studies have been conducted on online health information seeking behavior and its relationship with health beliefs, there are still gaps in identifying the exact and comprehensive relationships of these factors in Iran. The
Fatima Baji, Mohammad Hossein Haghighizadeh, Arezu Karimzadeh-Bardei   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source