Results 101 to 110 of about 5,060,474 (306)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Public management and essential public health functions [PDF]

The authors provide an overview of how different approaches to improving public sector management relate to so-called core or essential public health functions, such as disease surveillance, health education, monitoring and evaluation, workforce ...
Das Gupta Monica, Khaleghian, Peyvand
core  

Policy brief: investing in health information systems [PDF]

, 2013
Health information systems need to be recognised as an essential component of health service delivery in the Asia and Pacific regions, and valued for their ability to provide evidence for decision-making.
Hodge, Nicola, Power, Mark, Rodney, Anna
core  

The Role of Use Scenarios in Developing a Community Health Information System [PDF]

, 2000
Bharat Mehra, Ann Peterson Bishop, Imani Bazzell   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Marburg virus disease in Rwanda: an observational study of the first 10 days of outbreak response, clinical interventions, and outcomes

BMC Medicine
Background Marburg virus disease (MVD) is a highly fatal hemorrhagic fever with fatality rates between 33 and 88% in sub-Saharan Africa. Rwanda reported its first MVD outbreak on September 27, 2024.
Gashaija Absolomon, Canita R. Brent, Emmanuel C. Nyabyenda, Kelly Mwiza, Piero Irakiza, Zuki Chiwandire, Caroline Mudereri, Nathalie Umutoni, Sabine Musange, Eric Seruyange, Felix K. Rubuga, Theogene Twagiramugabe, Sanctus Musafiri, Edson Rwagasore, Jeanine Condo   +14 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Improving Personalized Consumer Health Search [PDF]

, 2018
CLEF 2018 eHealth Consumer Health Search task aims to investigate the effectiveness of the information retrieval systems in providing health information to common health consumers.
Gonçalves, Teresa, Yang, Hua
core  

Comparação de dados sobre homicídios entre dois sistemas de informação, Minas Gerais

Revista de Saúde Pública
INTRODUÇÃO: Existem muitas críticas à qualidade dos dados criminais existentes no Brasil, mas há pouco estudo sistemático para corroborar essas críticas.
Mônica S Monteiro de Castro, Renato M Assunção, Marcelo Ottoni Durante   +2 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source