Results 111 to 120 of about 5,124,765 (263)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Integrating procurement, prescription, and resistance data to strengthen antimicrobial stewardship: insights from a public health institution in India

Frontiers in Microbiology
IntroductionSustained and sub-optimal antimicrobial use drives antimicrobial resistance (AMR), a major health systems challenge in low- and middle-income countries (LMICs) such as India.
Vinay Modgil, Sundeep Sahay, Sundeep Sahay, Arunima Mukherjee, Arunima Mukherjee, Rashi Banta, Neha Joshi, Rashmi Surial, Subhash Thakur, Suvodeep Mazumdar, Sneha Roychowdhury, Neelam Taneja   +11 more
doaj   +1 more source

Online outsiders within\ud [PDF]

, 2010
Heightened attention to technological diffusion and informational inequalities is of\ud particular societal concern, given the increasing mediation of everyday life whereby\ud web-based initiatives abound and an increasing amount of information on ...
Cheong, Pauline Hope, Martin, Judith
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Telemedicine implementation and healthcare utilization in Rwanda: interrupted time series of babyl digital health services from 2015 to 2024

BMC Primary Care
Background Digital health platforms are transforming primary care delivery in low- and middle-income countries. Babyl provided Rwanda’s first nationwide telemedicine service from 2019 to September 2023, integrating nurse-led triage with physician ...
Felix K. Rubuga, Gashaija Absolomon, Thierry Claudien Uhawenimana, Yvonne Delphine Nsaba-Uwera, Jean Muhire, Jean Damascene Hagenimana, Emmanuel Christian Nyabyenda, Piero Irakiza, Muhammed Semakula, Eric Remera, James Humuza, Jeanine Condo   +11 more
doaj   +1 more source

Health and development : what can research contribute? [PDF]

This survey of the state of research on relations between health and economic development discusses first research on how development affects health and then research on how health affects development.
Birdsall, Nancy
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dual Clinical Practice (DCP) policy to improve the retention of human resources for health in Rwanda: a mid-term review using a cross-sectional and retrospective study design

BMC Health Services Research
Background Despite the high demand for public services globally, ensuring the quality of services provided by public health facilities is challenging.
Kizito Kayumba, Corneille Ntihabose, Sabine Musange Furere, Bernard Ngabo, Piero Irakiza, Felix K. Rubuga, Nathalie Umutoni, Ina Rukundo Kalisa, Pascal Birindabagabo, Emile Rwamasirabo, Emmanuel Kayibanda, Patience Mukundirukuri, Gashaija Absolomon, Sumana Dhanani, Jeanine Condo   +14 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source