Results 101 to 110 of about 1,959,318 (304)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Leveraging Health Information Technology Effectively for Performance Improvement in Home Health Care

, 2016
Health information technology (IT) becomes a critical tool to support performance improvement initiatives in home health agencies (HHAs) as home care utilization and expenditures increase.
Alhuwail, Dari
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparação de dados sobre homicídios entre dois sistemas de informação, Minas Gerais

Revista de Saúde Pública
INTRODUÇÃO: Existem muitas críticas à qualidade dos dados criminais existentes no Brasil, mas há pouco estudo sistemático para corroborar essas críticas.
Mônica S Monteiro de Castro, Renato M Assunção, Marcelo Ottoni Durante   +2 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Other title: Kansas 2014 Statewide Farmworker Health Program farmworker survey results

, 2015
Title from caption."The Kansas Statewide Farmworker Health Program (KSFHP) identified fifty questions from the Behavioral Risk Factor Surveillance System (BRFSS) to survey 497 adult farmworkers, age 18 and over in Kansas in 2014.
Kansas Statewide Farmworker Health Program.
core  

Marburg virus disease in Rwanda: an observational study of the first 10 days of outbreak response, clinical interventions, and outcomes

BMC Medicine
Background Marburg virus disease (MVD) is a highly fatal hemorrhagic fever with fatality rates between 33 and 88% in sub-Saharan Africa. Rwanda reported its first MVD outbreak on September 27, 2024.
Gashaija Absolomon, Canita R. Brent, Emmanuel C. Nyabyenda, Kelly Mwiza, Piero Irakiza, Zuki Chiwandire, Caroline Mudereri, Nathalie Umutoni, Sabine Musange, Eric Seruyange, Felix K. Rubuga, Theogene Twagiramugabe, Sanctus Musafiri, Edson Rwagasore, Jeanine Condo   +14 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Serbian Health Information System (HIS) improvements 2021–2024: comparison study using stages of continuous improvement (SOCI) methodology

Health Research Policy and Systems
Background The Health Information System (HIS) in public healthcare services in Serbia was introduced in 2008, with the first comprehensive evaluation of its maturity conducted in 2021.
Bosiljka Djikanovic, Milan Kovacevic, Isidora Smigic, Marija Cvejic, Emilija Nicic, Caitlin Madevu-Matson, Steve Ollis, Vasa Curcin, Alimou Barry, Stephanie Watson-Grant   +9 more
doaj   +1 more source