Results 131 to 140 of about 5,060,474 (306)

Roundtable discussion- The architecture matters in health and non-health information systems: The case of the microservice architecture paradigm [PDF]

, 2022
M Éric Chartré, Gabriel Morais, Marcos de Oliveira Morais   +2 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Social and cultural determinants of antibiotics prescriptions: analysis from a public community health centre in North India

Frontiers in Pharmacology
This paper explores the socio cultural and institutional determinants of irresponsible prescription and use of antibiotics which has implications for the rise and spread of antimicrobial resistance (AMR). This study describes the patterns of prescription
Arunima Mukherjee, Arunima Mukherjee, Rashmi Surial, Sundeep Sahay, Sundeep Sahay, Sundeep Sahay, Yogita Thakral, Yogita Thakral, Amandeep Gondara   +8 more
doaj   +1 more source

A mixed-methods assessment of Routine Health Information System (RHIS) Data Quality and Factors Affecting it, Addis Ababa City Administration, Ethiopia, 2020

, 2021
Biniyam Haftu, Girma Taye, Wondimu Ayele, Tigist Habtamu, Ephrem Biruk   +4 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Practice, enablers and barriers of health information system accountability framework in Northwest Ethiopia 2023 [PDF]

Biniyam Tilahun, Berhanu Fikadie Endehabtu, Amare Minyihun, Tajebew Zayede, Adane Nigusie, Asmamaw Atnafu, Lemma Derseh, Tesfahun Hialemarima, Getasew Amare   +8 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The negative impact of the COVID-19 pandemic on breast cancer tackle in Brazil’s public and private healthcare system: time series study between 2014 and 2022

BMC Health Services Research
Background The COVID-19 pandemic has overwhelmed the healthcare systems of many countries and negatively impacted the care of other diseases. Objective To evaluate the trend of screening mammograms, oncological breast surgeries, and breast cancer ...
Adriano Hyeda, Élide Sbardellotto Mariano Costa, Sérgio Candido Kowalski   +2 more
doaj   +1 more source

Evaluation of quality and use of health management information system in primary health care units of east Wollega zone, Oromia regional state, Ethiopia: [PDF]

, 2020
Mekonen Adimasu Kebede, Emiru Adeba, Melese Chego Cheme   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source