Results 91 to 100 of about 1,607,450 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Adoption of healthcare information technology and the impact on clinician behavior [PDF]

, 2009
Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2009."June 2009." Cataloged from PDF version of thesis.Includes bibliographical references (p.
Weinstein, Adam, S.M. Massachusetts Institute of Technology
core  

The influence of context and process when implementing e-health [PDF]

, 2009
<b>Background</b> Investing in computer-based information systems is notoriously risky, since many systems fail to become routinely used as part of everyday working practices, yet there is clear evidence about the management practices which ...
King, G, Heaney, D., Mair, F., Clark, Julia S, Mair, Frances, Heaney David, Mair Frances, Heaney, David, David Heaney, Frances Mair, Boddy, D., Clark Julia S, King, Gerry, Gerry King, Boddy David, David Boddy, Clark, J.S., Julia S Clark, Boddy, David, King Gerry   +19 more
core   +1 more source

Accelerating health information technology capabilities across England's National Health Service

The Lancet: Digital Health, 2021
Kathrin Cresswell, Aziz Sheikh, Robin Williams   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Embracing standard treatment manuals: information transfer to primary health workers in Papua New Guinea

, 2007
Papua New Guinean primary health care workers describe their Standard Treatment Manuals as like "a teacher" or "a doctor". This paper explores this glowing reference, looking at how Standard Treatment Manuals are utilised, through data collected in a ...
Davy, C.
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Investigation of the adoption of telemedicine technology in the Kuwaiti health system: Strategy and policy of implementation for overseas referral patients [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityThe cost of health care services is rising and the number of patients requesting overseas treatment from the Kuwait Government continues to increase ...
Buabbas, Ali
core  

HB 4150 draft report: supporting statewide community information exchange

, 2022
Covers OCLC #1368033657 and OCLC #1346317729.Title from PDF cover (viewed on February 2, 2023)."To fulfill the requirements of House Bill (HB) 4150 (2022) the Health Information Technology Oversight Council (HITOC) chartered a Community Information ...

core  

Development in the adoption of a national digital healthcare system and experience at taking new technology in use – changes from 2019 to 2022

Information Research: An International Electronic Journal
Introduction. The adoption of a national digital system for healthcare services in Iceland, and how people perceive their possibilities to adopt new technology is examined. Method.
Ágústa Pálsdóttir
doaj   +3 more sources