Results 101 to 110 of about 1,607,450 (303)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Ageing, learning, technology, and health management

, 2009
The world’s population is ageing rapidly. Ageing has an impact on all aspects of human life, including social, economic, cultural, and political. Understanding ageing is therefore an important issue for the 21st century.
Buys, Laurie, Sylvia Edwards, Boulton-Lewis, Gillian M., Edwards, Sylvia L., Gillian Boulton-Lewis, Partridge, Helen, Laurie Buys, Helen Patridge   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Promoting the meaningful use of health information for New Zealand consumers

, 2014
This New Zealand study surveyed consumers to gain an understanding of their health information requirements. Some 1783 questionnaires were available for descriptive statistical analyses.
Bycroft, Janine J., Boyd, MA, Honey, Michelle L.L., Roy, Dianne, Honey, Michelle L., Boyd, Mary-Anne, Roy, DE, Bycroft, JJ, Honey, Michelle, Raphael, Deborah   +9 more
core   +1 more source

Public Health Surveillance and Information Technology

Emerging Infectious Diseases, 1998
Robert W. Pinner
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Electronic health record data behavioral and oral

, 2020
Behavioral health providers use over 50 different EHR vendors -- Two-thirds of behavioral health agencies have adopted an EHR -- Challenges in EHR adoption for behavioral health agencies -- Looking ahead for behavioral health agencies -- More information

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Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Health information technology/health information exchange privacy and security glossary

, 2009
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF title page (viewed on Nov. 3, 2009)At head of

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Nurses and information technology [PDF]

, 2007
[Executive Summary]: Synopsis: A study of 10,000 nurses in Australia (44% response rate) on their use of information technology has clearly identified that nurses recognise benefits to adopting more information technology in the workplace.
Eley, Robert, Soar, Jeffrey, Buikstra, Elizabeth, Hegney, Desley, Fallon, Anthony Bruce, Gilmore, Victoria   +5 more
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