Results 161 to 170 of about 4,201,714 (253)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Developing and implementing a new health information technology innovation to improve patient safety in the Canadian context. [PDF]

Healthc Manage Forum
Hohl CM, Okpani AI, Kuziemsky C.
europepmc   +1 more source

Association of multimorbidity with the use of health information technology. [PDF]

Digit Health, 2023
Manning SE, Wang H, Dwibedi N, Shen C, Wiener RC, Findley PA, Mitra S, Sambamoorthi U.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The essential data elements for developing an internship monitoring system in Health Information Technology. [PDF]

BMC Med Educ
Safdari R, Ehtesham H.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

"The start of something that I hope could be greater": Health information technology tools for social care. [PDF]

SSM Qual Res Health
Bunce A, Morrissey S, Gold R, Donovan J, Pisciotta M, Gill I, Watkins SL, McGrath B, Gottlieb LM.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The need for more research into health information technology and maternal health outcomes. [PDF]

Womens Health (Lond)
Kim J, Chen M, White R.
europepmc   +1 more source

Call to digital health leaders: test and leverage this guideline to support health information technology implementation in practice. [PDF]

BMJ Health Care Inform, 2023
Harding SE, Day K, Carswell P.
europepmc   +1 more source