Results 61 to 70 of about 1,531,085 (252)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Smartphone-based psychotherapeutic micro-interventions to improve mood in a real-world setting

Frontiers in Psychology, 2016
Background: Using mobile communication technology as new personalized approach to treat mental disorders or to more generally improve quality of life is highly promising.
Gunther Meinlschmidt, Gunther Meinlschmidt, Jong-Hwan Lee, Esther Stalujanis, Angelo Belardi, Minkyung Oh, Eun Kyung Jung, Hyun-Chul Kim, Janine Alfano, Seung-Schik Yoo, Seung-Schik Yoo, Marion Tegethoff   +11 more
doaj   +1 more source

Functional safety of health information technology

Health Informatics Journal, 2012
In an effort to improve patient safety and reduce adverse events, there has been a rapid growth in the utilisation of health information technology (HIT). However, little work has examined the safety of the HIT systems themselves, the methods used in their development or the potential errors they may introduce into existing systems.
Chadwick, Liam, Fallon, Enda F., van der Putten, Wil J., Kirrane, Frank   +3 more
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Search for Health-Related Information in Internet by People Referred to Clinics of Training-Treatment Centers in Qom City, Iran, 2015

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2016
Background and Objectives: Health information include a wide spectrum of information, including information about diseases and how to prevent and treat them early, which is one of the main concerns for most people.
Zahra Jafary Nodoushan, Khadijeh Alipour Nodoushan, Hoda Ahmari Tehran, Narges Mohammad Salehi, Sarollah Shojaei, Azadeh Asgaryan, Mohsen Farahabadi   +6 more
doaj  

Information Behavior Model of e-Health Literacy for Online Health Information-seeking Effectiveness

JOIV: International Journal on Informatics Visualization
This study examines the growing imbalance between the availability and demand for medical resources, rising healthcare costs, and the critical role of accessible health information in disease prevention and public health.
Wang Xuewen, Masrah Azrifah Azmi Murad, Wu ZhangLi, Ismi Arif Ismail, Hayrol Azril Mohamed Shaffril   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Characteristics of the Health Information Technology Workforce in Georgia

Journal of the Georgia Public Health Association, 2019
Background: Advancement in medical technology, as well as the Health Information Technology for Economic and Clinical Health Act, has in part influenced the demand for health information technology (HIT) workers.
Imaobong Ekpo, Emmanuel Akowuah, Bettye Apenteng, Samuel Opoku   +3 more
doaj   +1 more source