Results 51 to 60 of about 1,531,085 (252)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Hippocratic Bargain and Health Information Technology [PDF]
Journal of Law, Medicine & Ethics, 2010 Since the fourth century, B.C.E., the Oath of Hippocrates has been the starting point in analyzing the obligations of physicians to protect the privacy and confidentiality interests of their patients. The pertinent provision of the Oath reads as follows: “What I may see or hear in the course of the treatment or even outside of the treatment in regard ...
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Current challenges in health information technology–related patient safety
Health Informatics Journal, 2020 We identify and describe nine key, short-term, challenges to help healthcare organizations, health information technology developers, researchers, policymakers, and funders focus their efforts on health information technology–related patient safety ...
Dean F Sittig +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
How to Evaluate Health Information Systems: Evaluation stages [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2011 The most important goal of health systems is improvement of quality, effectiveness and efficiency of health services. To achieve this goal, health care organizations should establish a proper structure for evaluating health information systems.
Farahnaz Sadoughi, Farzaneh Aminpour
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Perceptions of Electronic Health Records in Mississippi [PDF]
Journal of Systemics, Cybernetics and Informatics, 2014 This study reports perceptions of Electronic Health Record (EHR) adoption among key constituents in Mississippi to inform health care professionals and administrators about factors that influence the adoption and integration of EHRs into practice.
Jennifer L. Styron, Barry Cumbie
doaj
Challenges and Opportunities of Telemedicine: A Narrative Review Study
مدیریت اطلاعات سلامت, 2019 Immediate access to special clinical services remotely has an important role in transferring information, informing clinical diagnosis, and distance learning.
Shiva Mafi-Moradi +2 more
doaj +1 more source