Results 91 to 100 of about 12,232,204 (260)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The National Association of Health Occupations Teachers [PDF]
, 2015 The National Association of Health Occupations Teachers is a voluntary affiliated organization of the Health Occupations Division of the American Vocational Association.
Robichaux, Frances A., R.N., E.M.T., B.A.
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Harsh occupations, health status and social security [PDF]
, 2013 We study the optimal design of a social security system when individuals differ in health status and occupation. Health status is private information but is imperfectly correlated with occupation: individuals in harsh occupations are more likely to be in
Racionero, Maria, Pestieau, Pierre
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Health Disparities among Occupations in Taiwan: A Population Study
, 2012 Objectives: The first large-scale population survey was conducted in Taiwan to examine if and to what extent health disparities of four major chronic physical conditions exist among occupations.
Chen, P. +3 more
core +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Occupational determinants of health
Occupational determinants of health encompass a broad spectrum of workplace factors that wield considerable influence over an individual's holistic well-being, encompassing physical, mental, and social dimensions. This viewpoint aims to provide an expansive and nuanced examination, evaluation, and definition of these determinants, elucidating the ...
Aderonke Adetunji, Emmanuel Obeng-Gyasi
openaire +3 more sources
Choosing a health career: featuring Wee Pals, the Kid Power Gang
, 1979 DHEW publication, no. (HRA) 79-622. Encourages youth to consider careers in a variety of health-related occupations and profiles prominent health ...
Turner, Morrie
core