Results 71 to 80 of about 450,786 (264)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

New Occupations Emerging Across Industry Lines [PDF]

open access: yes, 1998
[Excerpt] Emerging occupations may be entirely new, created by changes in technology, society, markets, or regulations. They may also be existing ones that have been substantially modified by the same trends, and are increasing in employment.
Bureau of Labor Statistics
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Health Effects of Occupational Change [PDF]

open access: yes
Rapidly changing technologies and the growing openness of economies to international trade sometimes make entire occupations in the countries affected redundant.
Olga Lazareva
core  

Poverty Level Work in Western New York [PDF]

open access: yes, 2008
A large percentage of the jobs in western New York do not pay enough to keep a family safely out of poverty. Roughly 125,000 workers are in occupations for which the median wage is less than $20,000 per year – including salespeople, cashiers, security ...
Magavern, Sam
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

On the Sorting of Physicians across Medical Occupations [PDF]

open access: yes
We model the sorting of medical students across medical occupations and identify a mechanism that explains the possibility of differential productivity across occupations.
Courty, Pascal, Marschke, Gerald
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

The Impact of COVID-19 on Healthcare Students’ Academic Motivation: A Scoping Review

open access: yesInternational Medical Education
The COVID-19 pandemic caused major disruption to healthcare education worldwide, forcing rapid transitions to online learning, interruptions to clinical placements, and heightened uncertainty that profoundly influenced student experiences.
Thomas Mayers   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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