Results 231 to 240 of about 180,308,378 (306)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

The association between different insulin resistance indexes and bone health in the elderly. [PDF]

PLoS One
Lai T, Su Z, Chen R, Luo G, Xu S, Fang H, Yan H, Shen P, Hu K.   +8 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The mediating role of psychological capital in health behaviors among elderly nursing home residents. [PDF]

Front Psychol
Liao L, Li Y, Tian F, Wu J, Zhong J, He T, Li J.   +6 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Research on the impact of mutual elderly care on the physical and mental health of rural elderly in China. [PDF]

Sci Rep
Liu J, Liu X, Hu B, Liu G.
europepmc   +1 more source

Cognitive Social Capital in Community and Mental Health of the Elderly in China: The Moderating Effect of Age, Education, and Income. [PDF]

Healthcare (Basel)
Luo Y, Zhu S, Yang F, Li Y, Yan S, Jiang Y, Bai J.   +6 more
europepmc   +1 more source

Development of a conceptual framework of sexual health for married elderly women: An exploratory mixed method study. [PDF]

PLoS One
Saadatmand F, Savabi-Esfahani M, Heidari Z, Beigi M.   +3 more
europepmc   +1 more source