Results 71 to 80 of about 597,845 (266)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Declines in Activities in Daily Living of Older Adults with Sarcopenia Were Associated with Gait Speed

Medicina
Background and Objectives: Early assessment interventions are recommended for older adults with sarcopenia. Gait speed in older adults considerably decreases activities of daily living (ADL).
Ryo Sato, Yohei Sawaya, Tamaki Hirose, Takahiro Shiba, Lu Yin, Shuntaro Tsuji, Masahiro Ishizaka, Tomohiko Urano   +7 more
doaj   +1 more source

Health education as a strategy for the promotion of the health of the elderly: an integrative review

Revista Brasileira de Geriatria e Gerontologia, 2019
Objective: To identify the key issues and health education strategies for the health promotion for the elderly. Method: An integrative literature review was conducted during the months of March and April 2018, by means of the Virtual Health Library, in ...
Cícera Amanda Mota Seabra, Samyra Paula Lustoza Xavier, Yana Paula Coêlho Correia Sampaio, Mirna Fontenele de Oliveira, Glauberto da Silva Quirino, Maria de Fátima Antero Sousa Machado   +5 more
doaj   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Factors associated with the use of health services by elderly men in Brazil: a cross-sectional study

BMC Public Health, 2019
Background Studies have shown that older men use health services less frequently than women do. However, there has been little scientific research on this subject, making it necessary to investigate the influence of various factors on the profile of ...
Alana Maiara Brito Bibiano, Vanessa de Lima Silva, Rafael da Silveira Moreira   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Prevalence and associated factors of locomotive syndrome in young Japanese adults: a cross-sectional study

BMC Musculoskeletal Disorders
Background The onset of locomotive syndrome (LS) precedes that of frailty. Therefore, the first step in extending healthy life expectancy is to implement measures against LS in young adults.
Yohei Sawaya, Tamaki Hirose, Sora Onuma, Rina Nakajima, Seiya Fujita, Shiori Muroi, Ryo Sato, Lu Yin, Takahiro Shiba, Kaoru Kobayashi, Tomohiko Urano   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source