Results 81 to 90 of about 597,845 (266)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Revista Brasileira de Geriatria e GerontologiaO objetivo deste artigo foi identificar, com base na literatura, como a saúde do idoso e o envelhecimento têm sido abordados na formação universitária dos profissionais de saúde e o que vem sendo considerado relevante nesta temática.
Claudia Reinoso Araujo de Carvalho +1 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Maǧallaẗ Al-Turāṯ wa Al-TaṣmīmMany older people lose their ability to live independently, due to limited movement, chronic pain, weakness, or other psychological and physical problems, all of these factors can lead to loneliness and psychological distress to them, so they need a form
Dr. Mona Sayed Othman Badr Othman
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
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Sociodemographic and Health Profile of the Elderly in the city of João Pessoa – PB [PDF]
Revista Brasileira em Promoção da Saúde, 2012 Objective: To explore the sociodemographic profile and physical health of elderly enrolled in Family Health Units (USF) in the city of João Pessoa – PB, Brazil, and the factors associated with self-reported diagnoses in this population.
Laryssa Dantas Dias +4 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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