Results 131 to 140 of about 9,169,216 (420)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Evaluation of patient doses for routine digital radiography procedures toward establishing an institutional diagnostic reference levels: A case study in Sri Lanka

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract The present study was conducted as part of a comprehensive work to establish National Diagnostic Reference Levels (NDRLs) in Sri Lanka for the first time. DRLs can be used as an effective optimization tool for identifying unusually high or low patient doses during X‐ray examinations.
Sachith Welarathna, Sivakumar Velautham, Mihira Wanninayake, Sivananthan Sarasanandarajah   +3 more
wiley   +1 more source

Protocol for the operation of a breathing and vaping biomimetic robot to delineate real-time inhaled particle profile of electronic cigarettes

STAR Protocols, 2022
Summary: We recently developed a robotic human vaping mimetic real-time particle analyzer (HUMITIPAA) to evaluate the impact of change in chemical constituents and breathing profiles of electronic cigarettes (ECs) on potential pulmonary toxicity.
Rachel F. Bogdanoff, Alexander J. Kaiser, Kambez H. Benam   +2 more
doaj  

Social Network Structure is Predictive of Health and Wellness [PDF]

, 2018
Social networks influence health-related behaviors, such as obesity and smoking. While researchers have studied social networks as a driver for diffusion of influences and behaviors, it is less understood how the structure or topology of the network, in itself, impacts an individual's health behaviors and wellness state.
arxiv   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Penetrating particle ANalyzer (PAN)

, 2019
PAN is a scientific instrument suitable for deep space and interplanetary missions. It can precisely measure and monitor the flux, composition, and direction of highly penetrating particles ($> \sim$100 MeV/nucleon) in deep space, over at least one full ...
Ambrosi, G., Azzarello, P., Bergmann, B., Bertucci, B., Cadoux, F., Campbell, M., Duranti, M., Ionica, M., Kole, M., Krucker, S., Maehlum, G., Meier, D., Paniccia, M., Pinsky, L., Plainaki, C., Pospisil, S., Stein, T., Thonet, P. A., Tomassetti, N., Tykhonov, A., Wu, X.   +20 more
core   +1 more source

A Hybrid Approach for Fusing Physics and Data for Failure Prediction

International Journal of Prognostics and Health Management, 2016
This work describes the architecture for developing physics of failure models, derived as a function of machine sensor data, and integrating with data pertaining to other relevant factors like geography, manufacturing, environment, customer and ...
Prashanth Pillai, Anshul Kaushik, Shivanand Bhavikatti, Arjun Roy, Virendra Kumar   +4 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Attempt of modelling the Technnological Acceleration [PDF]

In this paper, we study the technological acceleration whithin a new frame work wich extends models used in the literature. The objective of our research is then to construct a global model of evaluation of the technological acceleration by two methods ...
Ajeddi, Majid
core   +1 more source

Health Physics (보건 물리학) in South Korea: Building a Research Community in a Post-Colonial Society, 1959-early 1970s. [PDF]

NTM, 2022
DiMoia JP.
europepmc   +1 more source