Results 171 to 180 of about 11,022,733 (387)

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

open access: yesAdvanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang   +11 more
wiley   +1 more source

Difference-in-Differences for Health Policy and Practice: A Review of Modern Methods [PDF]

open access: yesarXiv
Difference-in-differences (DiD) is the most popular observational causal inference method in health policy, employed to evaluate the real-world impact of policies and programs. To estimate treatment effects, DiD relies on the "parallel trends assumption", that on average treatment and comparison groups would have had parallel trajectories in the ...
arxiv  

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

open access: yesAdvanced Science, EarlyView.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope   +13 more
wiley   +1 more source

Health professions education and public policy

open access: bronze, 1978
R M Magraw, Danushka Fox, June Weston
openalex   +1 more source

Cation‐Anchoring‐Induced Efficient n‐Type Thermo‐Electric Ionogel with Ultra‐High Thermopower

open access: yesAdvanced Science, EarlyView.
An n‐type thermoelectric ion gel with excellent thermoelectric, mechanical, and sensing properties is fabricated via photopolymerization, leveraging an imidazole cation anchoring strategy to enhance thermoelectric performance and multiple hydrogen bonds from bacterial cellulose to improve mechanical strength. Abstract Ionogels have emerged as promising
Wenchao Zhen   +7 more
wiley   +1 more source

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