Results 151 to 160 of about 12,227,603 (310)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Malta: health system review

, 2017
xix, 137 p.Maltese life expectancy is high and people spend on average close to 90% of their lifespan in good health. Malta has recently increased the proportion of GDP spent on health to above the EU average, though the private part of that remains ...
Azzopardi-Muscat, Natasha, Merkur, Sherry, Calleja, Neville, European Observatory on Health Systems and Policies, Buttigieg, Stefan, World Health Organization. Regional Office for Europe   +5 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Refugee and migrant health system review: challenges and opportunities for long-term health system strengthening in Czechia

x, 43 p.This report presents the findings of a joint review conducted by the World Health Organization and the Ministry of Health of Czechia to assess the health system response to the large-scale arrival of refugees from Ukraine following the Russian ...
World Health Organization
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Seventh general programme of work covering the period 1984-1989

, 1982
Russian version of nos. 1-8 bound together (barcode no. 0072069)153 p.Sets out the priorities and lines of action, in the health and other sectors, that directed the work of WHO during the period 1984-1989. Priorities reflect the Organizations commitment
World Health Organization
core  

Serviço de Atendimento Móvel de Urgência: análise da política brasileira

Revista de Saúde Pública
OBJETIVO: Analisar a conformação da política de atenção móvel às urgências no Brasil. PROCEDIMENTOS METODOLÓGICOS: Com base no referencial da análise de políticas públicas, foram realizados: revisão bibliográfica, análise de documentos e dados oficiais e
Cristiani Vieira Machado, Fernanda Gonçalves Ferreira Salvador, Gisele O'Dwyer   +2 more
doaj  

Carga de cáncer del departamento de Nariño y subregiones, Colombia, 2010

Revista Facultad Nacional de Salud Pública, 2014
Resumen Objetivo: medir la carga de cáncer a partir del indicador Años de Vida Saludables Perdidos (avisa) en el Departamento de Nariño y subregiones.
Elizabeth Trujillo-Montalvo, Carlos Hidalgo-Patiño, Ángela Hidalgo-Eraso, Anderson Rocha-Buelvas   +3 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source