Results 161 to 170 of about 12,227,603 (310)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Priorities for research to take forward the health equity policy agenda.

, 2006
94895
Dachs, Norberto, WHO Task Force on Research Priorities for Equity in Health, Braveman, Paula, Ostlin, Piroska, WHO Equity Team   +4 more
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Eurohealth: priorities for health systems strengthening in the WHO European Region

, 2016
60 p.This issue of Eurohealth looks at how Member States across the European Region are strengthening their health systems in line with the strategic document “Priorities for healthsystems strengthening in the WHO European Region 2015–2020: walking the ...
European Observatory on Health Systems and Policies
core  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Perceived Healthcare Priorities, Barriers, and Preferences When Selecting Private or Governmental Healthcare Services Among a Sample of University Affiliates from Saudi Arabia

Patient Preference and Adherence
Ibrahim M Gosadi, Mohammad A Jareebi Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Saudi ArabiaCorrespondence: Ibrahim M Gosadi, Department of Family and Community Medicine, Faculty of Medicine, Jazan ...
Gosadi IM, Jareebi MA
doaj  

Antimicrobial Resistance in Somalia: Surveillance Gaps, Stewardship Barriers, and One Health Priorities. [PDF]

Infect Drug Resist
Jimale AM, Ali MA, Osman NH, Moallim AA, Mohamud AA, Ahmed ID, Abdi AM, Adam AA, Mohamud OM.   +8 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Rethinking health priorities for displaced populations through the integration of epigenetics and iterative reasoning. [PDF]

Public Health Rev
Milani A, Saiani L, Mazzocco K.
europepmc   +1 more source