Results 161 to 170 of about 993,777 (361)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A critical review of priority setting in the health sector: the methodology of the 1993 World Development Report [PDF]

, 1998
M Paalman
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Assessing Noninstitutionalized Asthma and COPD Patients' Priorities and Perceptions of Quality of Health Care: The Development of the QUOTE-CNSLD Instrument [PDF]

, 1997
Crétien van Campen, H. Sixma, Jan J. Kerssens, Loe Peters   +3 more
openalex   +1 more source

Decentralization and Public Delivery of Health Care Services in India [PDF]

This paper examines delivery of public health care services in India, in the broader context of decentralization. It provides an overview of the basic features and recent developments in intergovernmental fiscal relations and accountability mechanisms ...
Singh, Nirvikar
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Stakeholders’ Involvement in Health Technology Assessment in Kazakhstan, Poland and Bulgaria

Patient Preference and Adherence
Lyazzat Kulembekova,1 David Hailey,2 Maksut Kulzhanov,1 Adlet Tabarov,3 Svetlin Georgiev,4 Magdalena Jaworzynska,5 Antoniya Yordanova Yanakieva,4 Lyazzat Kosherbayeva1,6 1Health Policy and Management Department, Asfendiyarov Kazakh National Medical ...
Kulembekova L, Hailey D, Kulzhanov M, Tabarov A, Georgiev S, Jaworzynska M, Yanakieva AY, Kosherbayeva L   +7 more
doaj  

An analysis of the Vietnamese system of occupational safety and health and setting priorities with the analytical hierarchy process. [PDF]

, 1996
Shinya Matsuda
openalex   +1 more source

Acceptability and use of an online health priorities self-identification tool for older adults: A qualitative investigation. [PDF]

PEC Innov, 2023
Mroz EL, Hernandez-Bigos K, Esterson J, Kiwak E, Naik A, Tinetti ME.   +5 more
europepmc   +1 more source

The experiences and priorities of young people who care for their siblings in Tanzania and Uganda [PDF]

, 2010
This report presents key findings from a small-scale pilot research project that explored the experiences and priorities of young people caring for their siblings in sibling-headed households affected by AIDS in Tanzania and Uganda.
Evans, Ruth
core