Results 241 to 250 of about 1,128,412 (358)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Personalizing product sets to individual health priorities increases the healthfulness of hypothetical food choices in US adults. [PDF]

Sci Rep
Gustafson CR, Gitungwa H, Boron JB, Rose DJ.   +3 more
europepmc   +1 more source

Research: priorities to our public health [PDF]

, 2008
AMATO NETO, Vicente, PASTERNAK, Jacyr
core   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Leveraging State-Supported Continuing Education for Health Care Professionals to Address Public Health Priorities: A 5-Year Retrospective Case Study on the District of Columbia Program. [PDF]

Public Health Rep
Downing G, Mayewski Z, Tramontozzi LM, Plotke M, Ortique J.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research. [PDF]

J Pharmacol Exp Ther
Shurtleff D, Arensdorf A, Still PC, Gust SW, Chideya S, Hopp DC, Belfer I.   +6 more
europepmc   +1 more source

Do Moral Views Change during a Crisis? An Experiment on Health Care Priority Setting

Liam Strand, Erik Gustavsson, Gustav Tinghög   +2 more
openalex   +1 more source

Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis [PDF]

Jingyi Ma, Kimberly Eadie, Marij Schippers, Ahmed Hassan Fahal, Benoı̂t Laleu, Annelies Verbon, Wendy W. J. van de Sande   +6 more
openalex   +1 more source