Results 241 to 250 of about 220,169 (313)

Premature mortality projections to inform clinical practice and public health priorities. [PDF]

Lancet Reg Health West Pac
Islam SMS, Miranda JJ, Zoungas S, Maddison R.   +3 more
europepmc   +1 more source

A study of Priority-setting in Korean National Dental Health Insurance Scheme

, 2006
Ji-Hyoung Han, Yoon-Sook Hwang
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The future backbone of nutritional science: integrating public health priorities with system-oriented precision nutrition. [PDF]

Br J Nutr
Vergères G, Bochud M, Jotterand Chaparro C, Moretti D, Pestoni G, Probst-Hensch N, Rezzi S, Rohrmann S, Brück WM.   +8 more
europepmc   +1 more source

How do occupational therapy curricula align with priorities identified by occupational therapists to prepare graduates for working in mental health

, 2016
Justin Newton Scanlan, Geneviève Pépin, Priscilla Ennals, Pamela Meredith, Kirsti Haracz, Jayne S. Webster, Shelley Wright, Karen Arblaster   +7 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source