Results 111 to 120 of about 7,898,890 (358)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Use of e-cigarettes rising among junior and senior high school students in Taiwan
Tobacco Induced Diseases, 2018 Background According to the World Health Organization (WHO) report, e-cigarette use is doubling from 2008 to 2012 among adolescents. In Taiwan, e-cigarettes contain nicotine are controlled under Pharmaceutical Affairs Act since 2009, but it will violate ...
Ho-Yi Chung +7 more
doaj +1 more source
Promotion of Adult Health Maintenance Opportunities for Occupational Health Nurses [PDF]
, 1957 Jane W. Voscek
openalex +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Tobacco Induced Diseases, 2019 Objective World Health Organization (WHO) reported that tobacco causes more than 8 million people deaths a year. It was estimated that smoking kills 27,000 people annually in Taiwan, and on average one person dies from smoking-related diseases every 20 ...
Yi-Hsien Liu +7 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
, 2022 Health promotion is one the major interventions employed in healthcare delivery generally and primary care in particular. Health promotion enables individuals, families, populations and communities to adopt and/or adapt lifestyles that promote and improve health.
openaire +4 more sources
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Health promotion as public policy: The need for moral groundings [PDF]
, 1981 Edmund D. Pellegrino
openalex +1 more source