Results 241 to 250 of about 810,344 (312)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Correction: From sick care to healthspan: educating the longevity physician for health maintenance and health promotion. [PDF]

Biogerontology
Thor D, Barzilai D, Lyu YX, Spiru L.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Population-oriented health promotion and disease prevention interventions in primary healthcare: a scoping review of reviews. [PDF]

BMC Prim Care
Eriksson L, Olsson K, Hasson H, Bergström A, Costea VA, Holm E, Bäck A.   +6 more
europepmc   +1 more source

Sports-based mental health promotion for adolescents in rural Nepal: A pilot cluster-randomised controlled trial. [PDF]

PLOS Glob Public Health
Rose-Clarke K, Rimal D, Pradhan I, Lamichhane N, Abou Jaoude G, Hodsoll J, Morrison J, Luitel NP.   +7 more
europepmc   +1 more source

Frameworks for developing and evaluating public health interventions in primary prevention and health promotion: a scoping review. [PDF]

BMC Public Health
Muellmann S, Jahnel T, Pedrós Barnils N, Pan CC, Gerhardus A.   +4 more
europepmc   +1 more source

Functional Foods in Health Promotion and Disease Prevention: Innovations, Evidence and Challenges. [PDF]

Foods
Ma ZF, Liu S, Fu C, Zhou S, Lee YY.
europepmc   +1 more source

Curcumin as a Green Antibiotic Substitute: Mechanisms and Applications in Poultry Production and Health Promotion. [PDF]

Animals (Basel)
Tang X, Zhang B, Yang J, Xie Y, Xiong K.
europepmc   +1 more source

Mental gravity as a translational framework for mental health promotion. [PDF]

Front Hum Neurosci
Kent L.
europepmc   +1 more source