Results 71 to 80 of about 65,601,074 (263)
Research towards a healthier Ireland. Health Research Charities Ireland Position Paper 2019 [PDF]
, 2019 In this document we present key priorities for HRCI and our members. We are asking politicians to take them on board in preparation for budget 2020 and in developing party manifestos for the next general election. These recommendations are based on: •
Health Research Charities Ireland, /
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When Equity is Central to Research: Implications for Researchers and Consumers in the Research Team
International Journal of Integrated Care, 2017 This paper is a response to our recognition that approaches to equity and consumer involvement in research differed in emphasis between our researchers and jurisdictions.
Nicolette Sheridan +9 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Exploring the gut microbiome’s role in colorectal cancer: diagnostic and prognostic implications
Frontiers in ImmunologyThe intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis and prognosis, crucial for improving patient outcomes.
Guoming Chen +10 more
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Oil Spills and Human Health: Contributions of the Gulf of Mexico Research Initiative
GeoHealth, 2019 The Gulf of Mexico Research Initiative (GoMRI) was established in 2010 with $500 million in funding provided by British Petroleum over a 10‐year period to support research on the impacts of the Deepwater Horizon oil spill and recovery.
Ruth L. Eklund +3 more
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Microbiome Research Is Becoming the Key to Better Understanding Health and Nutrition
Frontiers in Genetics, 2018 The human microbiome has emerged as the crucial moderator in the interactions between food and our body. It is increasingly recognised that the microbiome can change our mind and health status, or switch on a wide range of diseases including cancer ...
Dirk Hadrich
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Health Research Board: Health Research in Action [PDF]
This year’s Health Research in Action highlights some of the many notable impacts and outcomes of our work. It includes a snapshot in numbers of recent work completed, followed by 19 success stories about wide-ranging health and social care research ...
Health Research Board
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Health Research Board annual report 2019 [English and Irish versions]
, 2020 Key initiatives delivered during 2019 included: • Funding a selection of new and existing awards worth more than €38 million, which are aligned to our strategic priorities; some examples include: > Collaborative Doctoral Awards to support doctoral ...
Health Research Board
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source