Results 111 to 120 of about 4,976,429 (317)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Other title: Results from Two Thousand Four Kansas Behavioral Risk Factor Surveillance System

open access: yes, 2006
"September 2006." "Partial funding for the 2004 Behavioral Risk Factor Survey was provided by cooperative agreement #U58/CCU722793-01 from the Centers for Disease Control and Prevention, Atlanta GA." Includes bibliographical references.Behavioral Risk ...
Kansas. Office of Health Promotion.
core  

Exploring the potential mechanisms of anti-pulmonary fibrosis effects of Luo Han Guo via network pharmacology, molecular docking, and experimental validation

open access: yesScientific Reports
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung condition distinguished by a complex etiology, poor prognosis and exhibiting high mortality rates.
Qinlin Cui   +11 more
doaj   +1 more source

Health & Health Risks

open access: yes, 2010
Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Other titles: Kansas Department of Health and Environment 1996 behavioral risk factor surveillance system Behavioral Risk Factor Surveillance System

open access: yes, 1998
"February 1998." "Funding for the 1996 Behavioral Risk Factor Survey was provided by a grant award from the Centers for Disease Control and Prevention, Atlanta, GA." Includes bibliographical references.Acknowledgements Executive Summary Table of ...
Kansas. Bureau for Disease Prevention and Health Promotion.
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Implicit and explicit risk perception, affect, and trust : an investigation of food "traffic lights"

open access: yes, 2014
Obesity is a health problem in many developed countries and is a growing problem worldwide. In an effort to improve food choices the "traffic lights" nutritional labelling system has been developed.
Burns, Calvin   +2 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A methodology for estimating SARS-CoV-2 importation risk by air travel into Canada between July and November 2021

open access: yesBMC Public Health
Background Estimating rates of disease importation by travellers is a key activity to assess both the risk to a country from an infectious disease emerging elsewhere in the world and the effectiveness of border measures.
Rachael M. Milwid   +7 more
doaj   +1 more source

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