Results 101 to 110 of about 4,245,224 (269)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sperm DNA methylation alterations induced by gestational arsenic exposure are established stepwise during spermatogenesis

Environmental Health and Preventive Medicine
Background: Gestational exposure to environmental toxicants has been reported to be associated with epigenetic alterations in the male germ line. We have previously demonstrated that gestational arsenic exposure induces characteristic DNA methylation ...
Takehiro Suzuki, Kazuyuki Okamura, Keiko Nohara   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Scientifically based educational program on healthy diet: features of nutrition to minimize harm to health caused by adverse (extreme) natural and climatic conditions

Якутский медицинский журнал
A scientifically based nutrition education programme has been developed covering nutrition peculiarities for people living on territories with extreme natural and climatic conditions.
N. V. Zaitseva, V. B. Alekseev, D. N. Lir, K. P. Luzhetsky, E. V. Khrushchyova   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Study of indicators of negative effects in children under the influence of adverse factors of the subarctic climate

Якутский медицинский журнал
We studied changes in the level of biochemical and general clinical indicators (thyroid-stimulating hormone, apolipoproteins, cortisol, serotonin, adrenaline, leukocytes, erythrocyte sedimentation rate) in children living under the adverse factors of the
N. V. Zaitseva, M. A. Zemlyanova, Yu. V. Koldibekova, E. V. Peskova   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate

Genes and Environment
Background Toluene diisocyanates (TDIs) are high-production-volume chemicals widely used in polyurethane manufacturing. A typical commercial-grade TDI (TDI; 2,4-toluene diisocyanate: 2,6-toluene diisocyanate; 80:20), CAS: 26471-62-5, is mutagenic in ...
Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source